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CDKN1A/p21 is an inhibitor of cyclin-dependent kinase (CDK) and the first identified target gene of p53

Coniferyl ferulate is a potent inhibitor of glutathione S-transferase ( GST ) ( IC = 0.3 M), which downregulates 50 P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance

This inhibitory effect is mediated by the metabolism of Gln by GFAT to glucosamine, which inhibits pentose cycle activity and reduces NADPH concentrations that are required for NOS activity [67]

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Researchers are now looking for the next generation of disease modifiers, including metabolism, inflammation, and brain lipid handling